Well I think, that when you get some dmg up and some health, then the run is realy easy and Azazel is one of the strongest champs overall in my oppinion. You might want to find an Algis somewhere and use something like the blank card just to reuse it, also if you unlocked "I'm drowsy" you can make most bosses realy easy. There are some combinations to get a super easy run, by using the d20 on many coins in the frontroom and having a battery in the store and 5 coins picked up to buy the battery, just spawning the room full of items as long as you'r able to rebuy the battery. Use bombs on the keeper, just for the chance of a steamsale. You might want to avoid the 11 round in the shop, if you got problems with the stain and he often spawns in a doublepack there. A combination of Habit can be realy usefull. I would recommend to take the 8 first runs in a row for most coins. If you find an item like Pyromaniac or host hat it makes the last fight easier, since you'r imune to explosions.
Take only Items you like if you get to a devil room.
It can be tough, though with a bit of practice it is easy.
It's a playthrough on normal greed mode with Azazel.
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